Ontology highlight
ABSTRACT:
SUBMITTER: Frank AC
PROVIDER: S-EPMC5789055 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Frank Adam C AC Huang Shan S Zhou Miou M Gdalyahu Amos A Kastellakis George G Silva Tawnie K TK Lu Elaine E Wen Ximiao X Poirazi Panayiota P Trachtenberg Joshua T JT Silva Alcino J AJ
Nature communications 20180129 1
Modeling studies suggest that clustered structural plasticity of dendritic spines is an efficient mechanism of information storage in cortical circuits. However, why new clustered spines occur in specific locations and how their formation relates to learning and memory (L&M) remain unclear. Using in vivo two-photon microscopy, we track spine dynamics in retrosplenial cortex before, during, and after two forms of episodic-like learning and find that spine turnover before learning predicts future ...[more]