Ontology highlight
ABSTRACT:
SUBMITTER: Wu B
PROVIDER: S-EPMC5789076 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Wu Baixing B Su Shichen S Patil Deepak P DP Liu Hehua H Gan Jianhua J Jaffrey Samie R SR Ma Jinbiao J
Nature communications 20180129 1
Human hnRNP A2/B1 is an RNA-binding protein that plays important roles in many biological processes, including maturation, transport, and metabolism of mRNA, and gene regulation of long noncoding RNAs. hnRNP A2/B1 was reported to control the microRNAs sorting to exosomes and promote primary microRNA processing as a potential m<sup>6</sup>A "reader." hnRNP A2/B1 contains two RNA recognition motifs that provide sequence-specific recognition of RNA substrates. Here, we determine crystal structures ...[more]