Targeting FLT3 Mutations in Acute Myeloid Leukemia.
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ABSTRACT:
SUBMITTER: El Fakih R
PROVIDER: S-EPMC5789277 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Publications
Targeting FLT3 Mutations in Acute Myeloid Leukemia.
El Fakih Riad R Rasheed Walid W Hawsawi Yousef Y Alsermani Maamoun M Hassanein Mona M
Cells 20180108 1
The FMS-like tyrosine kinase 3 (FLT3) pathway has an important role in cellular proliferation, survival, and differentiation. Acute myeloid leukemia (AML) patients with mutated FLT3 have a large disease burden at presentation and a dismal prognosis. A number of FLT3 inhibitors have been developed over the years. The first-generation inhibitors are largely non-specific, while the second-generation inhibitors are more specific and more potent. These inhibitors are used to treat patients with FLT3- ...[more]
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