Neurodegeneration and Sensorimotor Deficits in the Mouse Model of Traumatic Brain Injury.
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ABSTRACT:
SUBMITTER: Bhowmick S
PROVIDER: S-EPMC5789342 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
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Neurodegeneration and Sensorimotor Deficits in the Mouse Model of Traumatic Brain Injury.
Bhowmick Saurav S D'Mello Veera V Ponery Nizmi N Abdul-Muneer P M PM
Brain sciences 20180106 1
Traumatic brain injury (TBI) can result in persistent sensorimotor and cognitive deficits, which occur through a cascade of deleterious pathophysiological events over time. In this study, we investigated the hypothesis that neurodegeneration caused by TBI leads to impairments in sensorimotor function. TBI induces the activation of the caspase-3 enzyme, which triggers cell apoptosis in an in vivo model of fluid percussion injury (FPI). We analyzed caspase-3 mediated apoptosis by terminal deoxynuc ...[more]
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