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A fluorescent activatable probe for imaging intracellular Mg2+?.

ABSTRACT: An activatable BODIPY probe for in vitro detection and fluorescence cell imaging of free Mg2+ without interference from Ca2+ is described. Fluorescence amplification of the probe is observed upon detection of physiological concentrations of Mg2+ due to reduced rotation of the fluorophore and effective chelation by a quinolizine-based core.

SUBMITTER: Treadwell R

PROVIDER: S-EPMC5789582 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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A fluorescent activatable probe for imaging intracellular Mg2+ .

Treadwell Ryan R de Moliner Fabio F Subiros-Funosas Ramon R Hurd Toby T Knox Kirsten K Vendrell Marc M

Organic & biomolecular chemistry 20180101 2

An activatable BODIPY probe for in vitro detection and fluorescence cell imaging of free Mg2+ without interference from Ca2+ is described. Fluorescence amplification of the probe is observed upon detection of physiological concentrations of Mg2+ due to reduced rotation of the fluorophore and effective chelation by a quinolizine-based core. ...[more]

PMID: 29256562

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