Chloride intracellular channel 1 (CLIC1) contributes to modulation of cyclic AMP-activated whole-cell chloride currents in human bronchial epithelial cells.
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ABSTRACT:
SUBMITTER: Liu B
PROVIDER: S-EPMC5789713 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
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Chloride intracellular channel 1 (CLIC1) contributes to modulation of cyclic AMP-activated whole-cell chloride currents in human bronchial epithelial cells.
Liu Bo B Billington Charlotte K CK Henry Amanda P AP Bhaker Sangita K SK Kheirallah Alexander K AK Swan Caroline C Hall Ian P IP
Physiological reports 20180101 2
Chloride channels are known to play critical physiological roles in many cell types. Here, we describe the expression of anion channels using RNA Seq in primary cultures of human bronchial epithelial cells (hBECs). Chloride intracellular channel (CLIC) family members were the most abundant chloride channel transcripts, and CLIC1 showed the highest level of expression. In addition, we characterize the chloride currents in hBECs and determine how inhibition of CLIC1 via pharmacological and molecul ...[more]
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