Ontology highlight
ABSTRACT:
SUBMITTER: Fuzik T
PROVIDER: S-EPMC5789857 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Nature communications 20180130 1
Tick-borne encephalitis virus (TBEV) causes 13,000 cases of human meningitis and encephalitis annually. However, the structure of the TBEV virion and its interactions with antibodies are unknown. Here, we present cryo-EM structures of the native TBEV virion and its complex with Fab fragments of neutralizing antibody 19/1786. Flavivirus genome delivery depends on membrane fusion that is triggered at low pH. The virion structure indicates that the repulsive interactions of histidine side chains, w ...[more]