Ontology highlight
ABSTRACT:
SUBMITTER: Soto M
PROVIDER: S-EPMC5789941 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Soto Marion M Orliaguet Lucie L Reyzer Michelle L ML Manier M Lisa ML Caprioli Richard M RM Kahn C Ronald CR
Proceedings of the National Academy of Sciences of the United States of America 20180108 4
Mice subjected to cold or caloric deprivation can reduce body temperature and metabolic rate and enter a state of torpor. Here we show that administration of pyruvate, an energy-rich metabolic intermediate, can induce torpor in mice with diet-induced or genetic obesity. This is associated with marked hypothermia, decreased activity, and decreased metabolic rate. The drop in body temperature correlates with the degree of obesity and is blunted by housing mice at thermoneutrality. Induction of tor ...[more]