Ontology highlight
ABSTRACT:
SUBMITTER: Louie RHY
PROVIDER: S-EPMC5789945 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Louie Raymond H Y RHY Kaczorowski Kevin J KJ Barton John P JP Chakraborty Arup K AK McKay Matthew R MR
Proceedings of the National Academy of Sciences of the United States of America 20180108 4
HIV is a highly mutable virus, and over 30 years after its discovery, a vaccine or cure is still not available. The isolation of broadly neutralizing antibodies (bnAbs) from HIV-infected patients has led to renewed hope for a prophylactic vaccine capable of combating the scourge of HIV. A major challenge is the design of immunogens and vaccination protocols that can elicit bnAbs that target regions of the virus's spike proteins where the likelihood of mutational escape is low due to the high fit ...[more]