Ontology highlight
ABSTRACT:
SUBMITTER: Fadeev A
PROVIDER: S-EPMC5789956 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Fadeev Andrey A Mendoza-Garcia Patricia P Irion Uwe U Guan Jikui J Pfeifer Kathrin K Wiessner Stephanie S Serluca Fabrizio F Singh Ajeet Pratap AP Nüsslein-Volhard Christiane C Palmer Ruth H RH
Proceedings of the National Academy of Sciences of the United States of America 20180109 4
Mutations in anaplastic lymphoma kinase (ALK) are implicated in somatic and familial neuroblastoma, a pediatric tumor of neural crest-derived tissues. Recently, biochemical analyses have identified secreted small ALKAL proteins (FAM150, AUG) as potential ligands for human ALK and the related leukocyte tyrosine kinase (LTK). In the zebrafish <i>Danio rerio</i>, DrLtk, which is similar to human ALK in sequence and domain structure, controls the development of iridophores, neural crest-derived pigm ...[more]