Ontology highlight
ABSTRACT:
SUBMITTER: Ahn S
PROVIDER: S-EPMC5790006 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Ahn Seungkuk S Lee Keel Yong KY Parker Kevin Kit KK Shin Kwanwoo K
Scientific reports 20180130 1
The extracellular matrix (ECM) consists of polymerized protein monomers that form a unique fibrous network providing stability and structural support to surrounding cells. We harnessed the fibrillogenesis mechanisms of naturally occurring ECM proteins to produce artificial fibers with a heterogeneous protein makeup. Using ECM proteins as fibril building blocks, we created uniquely structured multi-component ECM fibers. Sequential incubation of fibronectin (FN) and laminin (LAM) resulted in self- ...[more]