Emerging Insights into Noncanonical Inflammasome Recognition of Microbes.
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ABSTRACT:
SUBMITTER: Russo AJ
PROVIDER: S-EPMC5790197 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Publications
Emerging Insights into Noncanonical Inflammasome Recognition of Microbes.
Russo Ashley J AJ Behl Bharat B Banerjee Ishita I Rathinam Vijay A K VAK
Journal of molecular biology 20171007 2
Inflammasomes are cytosolic multi-molecular complexes that sense intracellular microbial danger signals and metabolic perturbations. Inflammasome activation leads to the activation of caspase-1 and the release of pro-inflammatory cytokines IL-1β and IL-18 accompanied by cell death. An inflammasome-based surveillance machinery for Gram-negative bacterial infections has been recently discovered. This noncanonical inflammasome relies on sensing the cytosolic presence of lipopolysaccharide of Gram-n ...[more]
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