Ontology highlight
ABSTRACT:
SUBMITTER: Harigua-Souiai E
PROVIDER: S-EPMC5790279 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Harigua-Souiai Emna E Abdelkrim Yosser Zina YZ Bassoumi-Jamoussi Imen I Zakraoui Ons O Bouvier Guillaume G Essafi-Benkhadir Khadija K Banroques Josette J Desdouits Nathan N Munier-Lehmann Hélène H Barhoumi Mourad M Tanner N Kyle NK Nilges Michael M Blondel Arnaud A Guizani Ikram I
PLoS neglected tropical diseases 20180118 1
Leishmaniases are neglected parasitic diseases in spite of the major burden they inflict on public health. The identification of novel drugs and targets constitutes a research priority. For that purpose we used Leishmania infantum initiation factor 4A (LieIF), an essential translation initiation factor that belongs to the DEAD-box proteins family, as a potential drug target. We modeled its structure and identified two potential binding sites. A virtual screening of a diverse chemical library was ...[more]