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Long noncoding RNA LINP1 acts as an oncogene and promotes chemoresistance in breast cancer.


ABSTRACT: Recent studies have shown that long non-coding RNAs (lncRNAs) are involved in a number of biological processes; however, further study is still warranted to comprehensively reveal their functions. In this study, we showed that the lncRNA in non-homologous end joining (NHEJ) pathway 1 (LINP1) was related to breast cancer cell proliferation, metastasis and chemoresistance. Loss- and gain-of function studies were used to assess the role of LINP1 in promoting breast cancer progression. LINP1 knockdown mitigated breast cancer cell growth by inducing G1-phase cell cycle arrest and apoptosis. LINP1 also promoted breast cancer cell metastasis and influenced the expression of epithelial-mesenchymal transition-related markers. We identified p53 as a regulator of LINP1, and LINP1 overexpression could restore the metastatic effects of p53. Furthermore, LINP1 was upregulated in doxorubicin- and 5-fluorouracil-resistant cells and induced chemoresistance. We also observed that LINP1 enrichment played a critical functional role in chemoresistance by inhibiting chemotherapeutics-induced apoptosis. Moreover, LINP1 in tumors was associated with lower overall survival and disease-free survival. In conclusion, LINP1 may serve as a potential oncogene and chemoresistance-related regulator of breast cancer cells, suggesting that LINP1 might be a potent therapeutic target and might reduce chemoresistance in breast cancer.

SUBMITTER: Liang Y 

PROVIDER: S-EPMC5790352 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Long noncoding RNA LINP1 acts as an oncogene and promotes chemoresistance in breast cancer.

Liang Yiran Y   Li Yaming Y   Song Xiaojin X   Zhang Ning N   Sang Yuting Y   Zhang Hanwen H   Liu Ying Y   Chen Bing B   Zhao Wenjing W   Wang Lijuan L   Guo Renbo R   Yu Zhigang Z   Yang Qifeng Q  

Cancer biology & therapy 20180102 2


Recent studies have shown that long non-coding RNAs (lncRNAs) are involved in a number of biological processes; however, further study is still warranted to comprehensively reveal their functions. In this study, we showed that the lncRNA in non-homologous end joining (NHEJ) pathway 1 (LINP1) was related to breast cancer cell proliferation, metastasis and chemoresistance. Loss- and gain-of function studies were used to assess the role of LINP1 in promoting breast cancer progression. LINP1 knockdo  ...[more]

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