Ontology highlight
ABSTRACT:
SUBMITTER: LeBert D
PROVIDER: S-EPMC5790375 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
LeBert Danny D Squirrell Jayne M JM Freisinger Chrissy C Rindy Julie J Golenberg Netta N Frecentese Grace G Gibson Angela A Eliceiri Kevin W KW Huttenlocher Anna A
eLife 20180116
Tissue injury leads to early wound-associated reactive oxygen species (ROS) production that mediate tissue regeneration. To identify mechanisms that function downstream of redox signals that modulate regeneration, a <i>vimentin</i> reporter of mesenchymal cells was generated by driving GFP from the <i>vimentin</i> promoter in zebrafish. Early redox signaling mediated <i>vimentin</i> reporter activity at the wound margin. Moreover, both ROS and vimentin were necessary for collagen production and ...[more]