Ontology highlight
ABSTRACT:
SUBMITTER: Palladini A
PROVIDER: S-EPMC5790387 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Palladini Arianna A Thrane Susan S Janitzek Christoph M CM Pihl Jessica J Clemmensen Stine B SB de Jongh Willem Adriaan WA Clausen Thomas M TM Nicoletti Giordano G Landuzzi Lorena L Penichet Manuel L ML Balboni Tania T Ianzano Marianna L ML Giusti Veronica V Theander Thor G TG Nielsen Morten A MA Salanti Ali A Lollini Pier-Luigi PL Nanni Patrizia P Sander Adam F AF
Oncoimmunology 20180105 3
Overexpression of human epidermal growth factor receptor-2 (HER2) occurs in 20-30% of invasive breast cancers. Monoclonal antibody therapy is effective in treating HER2-driven mammary carcinomas, but its utility is limited by high costs, side effects and development of resistance. Active vaccination may represent a safer, more effective and cheaper alternative, although the induction of strong and durable autoantibody responses is hampered by immune-tolerogenic mechanisms. Using a novel virus-li ...[more]