Ontology highlight
ABSTRACT:
SUBMITTER: Yang H
PROVIDER: S-EPMC5790461 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Yang Haixiu H Zhang Yunpeng Y Wang Jiasheng J Wu Tan T Liu Siyao S Xu Yanjun Y Shang Desi D
Oncotarget 20171214 3
An important challenge in drug development is to gain insight into the mechanism of drug sensitivity. Looking for insights into the global relationships between drugs and their sensitivity genes would be expected to reveal mechanism of drug sensitivity. Here we constructed a drug-sensitivity gene network (DSGN) based on the relationships between drugs and their sensitivity genes, using drug screened genomic data from the NCI-60 cell line panel, including 181 drugs and 1057 sensitivity genes, and ...[more]