Ontology highlight
ABSTRACT:
SUBMITTER: Dey S
PROVIDER: S-EPMC5790523 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Dey Sanchareeka S Kumari Sharda S Kalainayakan Sarada Preeta SP Campbell James J Ghosh Poorva P Zhou Heling H FitzGerald Keely E KE Li Maoping M Mason Ralph P RP Zhang Li L Liu Li L
Oncotarget 20171228 3
Vascular disrupting agents (VDAs) represent a promising class of anti-cancer drugs for solid tumor treatment. Here, we aim to better understand the mechanisms underlying tumor reccurrence and treatment resistance following the administration of a VDA, combretastatin A-4 phosphate (CA4P). Firstly, we used photoacoustic tomography to noninvasively map the effect of CA4P on blood oxygen levels throughout subcutaneous non-small cell lung cancer (NSCLC) tumors in mice. We found that the oxygenation o ...[more]