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Electrochemical determination of an anti-hyperlipidimic drug pitavastatin at electrochemical sensor based on electrochemically pre-treated polymer film modified GCE.

ABSTRACT: An electrochemically pretreated silver macroporous (Ag MP) multiwalled carbon nanotube modified glassy carbon electrode (PAN-Ag MP-MWCNT-GCE) was fabricated for the selective determination of an anti-hyperlipidimic drug, pitavastatin (PST). The fabricated electrochemical sensor was characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The fabricated electrode was employed in quantifying and determining PST through differential pulse adsorptive stripping voltammetry (DPAdSV) and CV. The electrode fabrication proceeded with remarkable sensitivity to the determination of PST. The effect of various optimized parameters such as pH, scan rate (?), accumulation time (tacc), accumulation potential (Uacc) and loading volumes of Ag MP-MWCNT suspension were investigated to evaluate the performance of synthesized electrochemical sensor and to propose a simple, accurate, rapid and economical procedure for the quantification of PST in pharmaceutical formulations and biological fluids. A linear response of PST concentration in the range 2.0×10-7-1.6×10-6 M with low detection (LOD) and quantification (LOQ) limits of 9.66±0.04 nM and 32.25±0.07 nM, respectively, were obtained under these optimized conditions.

SUBMITTER: Pandit UJ

PROVIDER: S-EPMC5790704 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Electrochemical determination of an anti-hyperlipidimic drug pitavastatin at electrochemical sensor based on electrochemically pre-treated polymer film modified GCE.

Pandit Umar J UJ Naikoo Gowhar A GA Naikoo Gowhar A GA Sheikh Mehraj Ud Din MUD Khan Gulzar A GA Raj K K KK Limaye S N SN

Journal of pharmaceutical analysis 20170319 4

An electrochemically pretreated silver macroporous (Ag MP) multiwalled carbon nanotube modified glassy carbon electrode (PAN-Ag MP-MWCNT-GCE) was fabricated for the selective determination of an anti-hyperlipidimic drug, pitavastatin (PST). The fabricated electrochemical sensor was characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The fabricated electrode was employed in quantifying and determining PST through differential pulse adsorptive stripping volta ...[more]

PMID: 29404047

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Project description:BackgroundInterest in functionalized carbon nanotubes for many applications arises from a variety on the kind of modification atoms or molecules that are attached to it. Dopamine, the feel-good hormone, release by neurons and playing an important role in body systems. Abnormal dopamine levels cause nerve disorders such as Parkinson's disease and schizophrenia.ObjectivesThe aim of this study was the design and fabrication of electrochemical sensor based on MWCNTs and Pd nanoparticles for detection and determination of dopamine in biological samples.MethodsFor this purpose, we report the synthesis of pramipexole-functionalized MWCNTs (pp-MWCNTs) for efficient capture of palladium nanoparticles and fabrication of Pd/pp-MWCNTs nanocomposite. Morphological and structural characteristics of the nanocomposites were characterized using various techniques including field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX), and Fourier transform infrared spectroscopy (FT-IR).ResultsThis newly synthesized nanocomposite may have numerous applications in nanotechnology and sensing. We show that the synthesized nanocomposite reported here will be applicable for modifications of bare glassy carbon electrode (Pd/pp-MWCNTs/GCE) to sense of dopamine electrochemically. Two linear calibrations for dopamine are obtained over ranges of 0.01 to 10 μM and 10 to 200 μM with a detection limit of 1.4 nM. The Pd/pp-MWCNTs/GCE shows high stability and sensitivity, and an acceptable decrease of over-potential for the electrooxidation of dopamine that decreases interference in the analysis. The proposed Pd/pp-MWCNTs nanocomposite can be used as a voltammetric detector for dopamine monitoring in routine real sample analysis.ConclusionsThe proposed sensor showed high sensitivity and selectivity in sensing dopamine in biological samples. Graphical abstract Preparation of Pd/pp-MWCNTs/GCE for detection of dopamine.

Dataset Information

Electrochemical determination of an anti-hyperlipidimic drug pitavastatin at electrochemical sensor based on electrochemically pre-treated polymer film modified GCE.

Publications

Electrochemical determination of an anti-hyperlipidimic drug pitavastatin at electrochemical sensor based on electrochemically pre-treated polymer film modified GCE.

Similar Datasets

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