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Familial Adenomatous Polyposis with Multiple Helicobacter-negative Early Gastric Cancers Treated by Endoscopic Submucosal Dissection.


ABSTRACT: Stomach cancer rarely develops in patients with familial adenomatous polyposis (FAP), and Helicobacter pylori infection may increase the risk of FAP-related gastric cancer. We describe the case of a 64-year-old woman who developed multiple synchronous early gastric cancers without H. pylori infection. Nine cancer lesions were successfully treated by endoscopic submucosal dissection. An immunohistochemical analysis revealed that the tumors were positive for mucin (MUC)2, MUC6, and CDX2, but negative for MUC5AC, suggesting that the tumors were gastrointestinal mixed type. Periodical endoscopic surveillance is important for the detection of cancers at an early stage.

SUBMITTER: Yaguchi K 

PROVIDER: S-EPMC5790714 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Familial Adenomatous Polyposis with Multiple Helicobacter-negative Early Gastric Cancers Treated by Endoscopic Submucosal Dissection.

Yaguchi Katsuki K   Makazu Makomo M   Hirasawa Kingo K   Sugimori Makoto M   Kobayashi Ryosuke R   Sato Chiko C   Ikeda Ryosuke R   Fukuchi Takehide T   Ishii Yasuaki Y   Kaneko Hiroaki H   Shibata Wataru W   Yamanaka Shoji S   Inayama Yoshiaki Y   Maeda Shin S  

Internal medicine (Tokyo, Japan) 20171011 24


Stomach cancer rarely develops in patients with familial adenomatous polyposis (FAP), and Helicobacter pylori infection may increase the risk of FAP-related gastric cancer. We describe the case of a 64-year-old woman who developed multiple synchronous early gastric cancers without H. pylori infection. Nine cancer lesions were successfully treated by endoscopic submucosal dissection. An immunohistochemical analysis revealed that the tumors were positive for mucin (MUC)2, MUC6, and CDX2, but negat  ...[more]

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