TRPC5 Does Not Cause or Aggravate Glomerular Disease.
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ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC5791075 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
TRPC5 Does Not Cause or Aggravate Glomerular Disease.
Wang Xuexiang X Dande Ranadheer R RR Yu Hao H Samelko Beata B Miller Rachel E RE Altintas Mehmet M MM Reiser Jochen J
Journal of the American Society of Nephrology : JASN 20171023 2
Transient receptor potential channel 5 (TRPC5) is highly expressed in brain and kidney and mediates calcium influx and promotes cell migration. In the kidney, loss of TRPC5 function has been reported to benefit kidney filter dynamics by balancing podocyte cytoskeletal remodeling. However, <i>in vivo</i> gain-in-function studies of TRPC5 with respect to kidney function have not been reported. To address this gap, we developed two transgenic mouse models on the C57BL/6 background by overexpressing ...[more]
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