Ontology highlight
ABSTRACT:
SUBMITTER: Hajarnis S
PROVIDER: S-EPMC5791084 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Hajarnis Sachin S Yheskel Matanel M Williams Darren D Brefort Thomas T Glaudemans Bob B Debaix Huguette H Baum Michel M Devuyst Olivier O Patel Vishal V
Journal of the American Society of Nephrology : JASN 20171011 2
microRNAs (miRNAs) are sequence-specific inhibitors of post-transcriptional gene expression. The physiologic function of these noncoding RNAs in postnatal renal tubules still remains unclear. Surprisingly, they appear to be dispensable for mammalian proximal tubule (PT) function. Here, we examined the effects of miRNA suppression in collecting ducts (CDs). To conclusively evaluate the role of miRNAs, we generated three mouse models with CD-specific inactivation of key miRNA pathway genes <i>Dice ...[more]