Ontology highlight
ABSTRACT:
SUBMITTER: Leroux-Roels G
PROVIDER: S-EPMC5791588 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Leroux-Roels Geert G Lattanzi Maria M Solis Claudia Dovali CD Contorni Mario M Costantini Marco M Moraschini Luca L Bardelli Monia M Bertholet Sylvie S Borgogni Erica E Buricchi Francesca F Cantisani Rocco R Faenzi Elisa E Finco Oretta O Leuzzi Rosanna R Pizza Mariagrazia M Rosa Domenico D Schiavetti Francesca F Seubert Anja A Spensieri Fabiana F Volpini Gianfranco G Zedda Luisanna L Giudice Giuseppe Del GD Galgani Ilaria I
Human vaccines & immunotherapeutics 20171127 1
Despite high vaccination coverage worldwide, pertussis has re-emerged in many countries. This randomized, controlled, observer-blind phase I study and extension study in Belgium (March 2012-June 2015) assessed safety and immunogenicity of investigational acellular pertussis vaccines containing genetically detoxified pertussis toxin (PT) (NCT01529645; NCT02382913). 420 healthy adults (average age: 26.8 ± 5.5 years, 60% female) were randomized to 1 of 10 vaccine groups: 3 investigational aP vaccin ...[more]