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Residue-Specific Peptide Modification: A Chemist's Guide.

ABSTRACT: Advances in bioconjugation and native protein modification are appearing at a blistering pace, making it increasingly time consuming for practitioners to identify the best chemical method for modifying a specific amino acid residue in a complex setting. The purpose of this perspective is to provide an informative, graphically rich manual highlighting significant advances in the field over the past decade. This guide will help triage candidate methods for peptide alteration and will serve as a starting point for those seeking to solve long-standing challenges.

SUBMITTER: deGruyter JN

PROVIDER: S-EPMC5792174 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Residue-Specific Peptide Modification: A Chemist's Guide.

deGruyter Justine N JN Malins Lara R LR Baran Phil S PS

Biochemistry 20170717 30

Advances in bioconjugation and native protein modification are appearing at a blistering pace, making it increasingly time consuming for practitioners to identify the best chemical method for modifying a specific amino acid residue in a complex setting. The purpose of this perspective is to provide an informative, graphically rich manual highlighting significant advances in the field over the past decade. This guide will help triage candidate methods for peptide alteration and will serve as a st ...[more]

PMID: 28653834

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