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CITU: A Peptide and Decarboxylative Coupling Reagent.

ABSTRACT: Tetrachloro-N-hydroxyphthalimide tetramethyluronium hexafluorophosphate (CITU) is disclosed as a convenient and economical reagent for both acylation and decarboxylative cross-coupling chemistries. Within the former set of reactions, CITU displays reactivity similar to that of common coupling reagents, but with increased safety and reduced cost. Within the latter, increased yields, more rapid conversion, and a simplified procedure are possible across a range of reported decarboxylative transformations.

SUBMITTER: deGruyter JN

PROVIDER: S-EPMC5792187 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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CITU: A Peptide and Decarboxylative Coupling Reagent.

deGruyter Justine N JN Malins Lara R LR Wimmer Laurin L Clay Khalyd J KJ Lopez-Ogalla Javier J Qin Tian T Cornella Josep J Liu Zhiqing Z Che Guanda G Bao Denghui D Stevens Jason M JM Qiao Jennifer X JX Allen Martin P MP Poss Michael A MA Baran Phil S PS

Organic letters 20171108 22

Tetrachloro-N-hydroxyphthalimide tetramethyluronium hexafluorophosphate (CITU) is disclosed as a convenient and economical reagent for both acylation and decarboxylative cross-coupling chemistries. Within the former set of reactions, CITU displays reactivity similar to that of common coupling reagents, but with increased safety and reduced cost. Within the latter, increased yields, more rapid conversion, and a simplified procedure are possible across a range of reported decarboxylative transform ...[more]

PMID: 29115835

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