Dataset Information

DNA-assisted swarm control in a biomolecular motor system.

ABSTRACT: In nature, swarming behavior has evolved repeatedly among motile organisms because it confers a variety of beneficial emergent properties. These include improved information gathering, protection from predators, and resource utilization. Some organisms, e.g., locusts, switch between solitary and swarm behavior in response to external stimuli. Aspects of swarming behavior have been demonstrated for motile supramolecular systems composed of biomolecular motors and cytoskeletal filaments, where cross-linkers induce large scale organization. The capabilities of such supramolecular systems may be further extended if the swarming behavior can be programmed and controlled. Here, we demonstrate that the swarming of DNA-functionalized microtubules (MTs) propelled by surface-adhered kinesin motors can be programmed and reversibly regulated by DNA signals. Emergent swarm behavior, such as translational and circular motion, can be selected by tuning the MT stiffness. Photoresponsive DNA containing azobenzene groups enables switching between solitary and swarm behavior in response to stimulation with visible or ultraviolet light.

SUBMITTER: Keya JJ

PROVIDER: S-EPMC5792447 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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DNA-assisted swarm control in a biomolecular motor system.

Keya Jakia Jannat JJ Suzuki Ryuhei R Kabir Arif Md Rashedul AMR Inoue Daisuke D Asanuma Hiroyuki H Sada Kazuki K Hess Henry H Kuzuya Akinori A Kakugo Akira A

Nature communications 20180131 1

In nature, swarming behavior has evolved repeatedly among motile organisms because it confers a variety of beneficial emergent properties. These include improved information gathering, protection from predators, and resource utilization. Some organisms, e.g., locusts, switch between solitary and swarm behavior in response to external stimuli. Aspects of swarming behavior have been demonstrated for motile supramolecular systems composed of biomolecular motors and cytoskeletal filaments, where cro ...[more]

PMID: 29386522

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Project description:The working hypothesis in this project is that gaze interactions play a central role in structuring the joint control and guidance strategy of the human operator performing spatial tasks. Perceptual guidance and control is the idea that the visual and motor systems form a unified perceptuo-motor system where necessary information is naturally extracted by the visual system. As a consequence, the response of this system is constrained by the visual and motor mechanisms and these effects should manifest in the behavioral data. Modeling the perceptual processes of the human operator provides the foundation necessary for a systems-based approach to the design of control and display systems used by remotely operated vehicles. This paper investigates this hypothesis using flight tasks conducted with remotely controlled miniature rotorcraft, taking place in indoor settings that provide rich environments to investigate the key processes supporting spatial interactions. This work also applies to spatial control tasks in a range of application domains that include tele-operation, gaming, and virtual reality. The human-in-the-loop system combines the dynamics of the vehicle, environment, and human perception⁻action with the response of the overall system emerging from the interplay of perception and action. The main questions to be answered in this work are as follows: (i) what is the general control and guidance strategy of the human operator, and (ii) how is information about the vehicle and environment extracted visually by the operator. The general approach uses gaze as the primary sensory mechanism by decoding the gaze patterns of the pilot to provide information for estimation, control, and guidance. This work differs from existing research by taking what have largely been conceptual ideas on action⁻perception and structuring them to be implemented for a real-world problem. The paper proposes a system model that captures the human pilot's perception⁻action loop; the loop that delineates the main components of the pilot's perceptuo-motor system, including estimation of the vehicle state and task elements based on operator gaze patterns, trajectory planning, and tracking control. The identified human visuo-motor model is then exploited to demonstrate how the perceptual and control functions system can be augmented to reduce the operator workload.

Dataset Information

DNA-assisted swarm control in a biomolecular motor system.

Publications

DNA-assisted swarm control in a biomolecular motor system.

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