Ontology highlight
ABSTRACT:
SUBMITTER: DeWaal D
PROVIDER: S-EPMC5792493 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
DeWaal Dannielle D Nogueira Veronique V Terry Alexander R AR Patra Krushna C KC Jeon Sang-Min SM Guzman Grace G Au Jennifer J Long Christopher P CP Antoniewicz Maciek R MR Hay Nissim N
Nature communications 20180131 1
Hepatocellular carcinoma (HCC) cells are metabolically distinct from normal hepatocytes by expressing the high-affinity hexokinase (HK2) and suppressing glucokinase (GCK). This is exploited to selectively target HCC. Hepatic HK2 deletion inhibits tumor incidence in a mouse model of hepatocarcinogenesis. Silencing HK2 in human HCC cells inhibits tumorigenesis and increases cell death, which cannot be restored by GCK or mitochondrial binding deficient HK2. Upon HK2 silencing, glucose flux to pyruv ...[more]