Ontology highlight
ABSTRACT:
SUBMITTER: Wong TN
PROVIDER: S-EPMC5792556 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Wong Terrence N TN Miller Christopher A CA Jotte Matthew R M MRM Bagegni Nusayba N Baty Jack D JD Schmidt Amy P AP Cashen Amanda F AF Duncavage Eric J EJ Helton Nichole M NM Fiala Mark M Fulton Robert S RS Heath Sharon E SE Janke Megan M Luber Kierstin K Westervelt Peter P Vij Ravi R DiPersio John F JF Welch John S JS Graubert Timothy A TA Walter Matthew J MJ Ley Timothy J TJ Link Daniel C DC
Nature communications 20180131 1
Hematopoietic clones harboring specific mutations may expand over time. However, it remains unclear how different cellular stressors influence this expansion. Here we characterize clonal hematopoiesis after two different cellular stressors: cytotoxic therapy and hematopoietic transplantation. Cytotoxic therapy results in the expansion of clones carrying mutations in DNA damage response genes, including TP53 and PPM1D. Analyses of sorted populations show that these clones are typically multilinea ...[more]