Ontology highlight
ABSTRACT:
SUBMITTER: Sato E
PROVIDER: S-EPMC5793106 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Sato Emiko E Saigusa Daisuke D Mishima Eikan E Uchida Taeko T Miura Daisuke D Morikawa-Ichinose Tomomi T Kisu Kiyomi K Sekimoto Akiyo A Saito Ritsumi R Oe Yuji Y Matsumoto Yotaro Y Tomioka Yoshihisa Y Mori Takefumi T Takahashi Nobuyuki N Sato Hiroshi H Abe Takaaki T Niwa Toshimitsu T Ito Sadayoshi S
Toxins 20171228 1
Elevated circulating uremic toxins are associated with a variety of symptoms and organ dysfunction observed in patients with chronic kidney disease (CKD). Indoxyl sulfate (IS) and <i>p</i>-cresyl sulfate (PCS) are representative uremic toxins that exert various harmful effects. We recently showed that IS induces metabolic alteration in skeletal muscle and causes sarcopenia in mice. However, whether organ-specific accumulation of IS and PCS is associated with tissue dysfunction is still unclear. ...[more]