Ontology highlight
ABSTRACT:
SUBMITTER: Chandler PD
PROVIDER: S-EPMC5793283 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Chandler Paulette D PD Tobias Deirdre K DK Wang Lu L Smith-Warner Stephanie A SA Chasman Daniel I DI Rose Lynda L Giovannucci Edward L EL Buring Julie E JE Ridker Paul M PM Cook Nancy R NR Manson JoAnn E JE Sesso Howard D HD
Nutrients 20180109 1
Some observational studies suggest an inverse association between circulating 25-hydroxyvitamin D (25OHD) and cancer incidence and mortality. We conducted a Mendelian randomization analysis of the relationship between a vitamin D genetic risk score (GRS, range 0-10), comprised of five single nucleotide polymorphisms (SNPs) of vitamin D status in the DHCR7, CYP2R1 and GC genes and cancer risk among women. Analysis was performed in the Women's Genome Health Study (WGHS), including 23,294 women of ...[more]