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Novel agents for pancreatic ductal adenocarcinoma: emerging therapeutics and future directions.


ABSTRACT: A poor prognosis of pancreatic ductal adenocarcinoma (PDAC) associated with chemoresistance has not changed for the past three decades. A multidisciplinary diagnosis followed by surgery and chemo(radiation)therapy is the main treatment approach. However, gemcitabine- and 5-fluorouracil-based therapies did not present satisfying outcomes. Novel regimens targeting pancreatic cancer cells, the tumor microenvironment, and immunosuppression are emerging. Biomarkers concerning the treatment outcome and patient selection are being discovered in preclinical or clinical studies. Combination therapies of classic chemotherapeutic drugs and novel agents or novel therapeutic combinations might bring hope to the dismal prognosis for PDAC patients.

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5793409 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Novel agents for pancreatic ductal adenocarcinoma: emerging therapeutics and future directions.

Zhang Yiyin Y   Yang Chao C   Cheng He H   Fan Zhiyao Z   Huang Qiuyi Q   Lu Yu Y   Fan Kun K   Luo Guopei G   Jin Kaizhou K   Wang Zhengshi Z   Liu Chen C   Yu Xianjun X  

Journal of hematology & oncology 20180131 1


A poor prognosis of pancreatic ductal adenocarcinoma (PDAC) associated with chemoresistance has not changed for the past three decades. A multidisciplinary diagnosis followed by surgery and chemo(radiation)therapy is the main treatment approach. However, gemcitabine- and 5-fluorouracil-based therapies did not present satisfying outcomes. Novel regimens targeting pancreatic cancer cells, the tumor microenvironment, and immunosuppression are emerging. Biomarkers concerning the treatment outcome an  ...[more]

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