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Rationale of the FIBROTARGETS study designed to identify novel biomarkers of myocardial fibrosis.

ABSTRACT: AIMS:Myocardial fibrosis alters the cardiac architecture favouring the development of cardiac dysfunction, including arrhythmias and heart failure. Reducing myocardial fibrosis may improve outcomes through the targeted diagnosis and treatment of emerging fibrotic pathways. The European-Commission-funded 'FIBROTARGETS' is a multinational academic and industrial consortium with the main aims of (i) characterizing novel key mechanistic pathways involved in the metabolism of fibrillary collagen that may serve as biotargets, (ii) evaluating the potential anti-fibrotic properties of novel or repurposed molecules interfering with the newly identified biotargets, and (iii) characterizing bioprofiles based on distinct mechanistic phenotypes involving the aforementioned biotargets. These pathways will be explored by performing a systematic and collaborative search for mechanisms and targets of myocardial fibrosis. These mechanisms will then be translated into individualized diagnostic tools and specific therapeutic pharmacological options for heart failure. METHODS AND RESULTS:The FIBROTARGETS consortium has merged data from 12 patient cohorts in a common database available to individual consortium partners. The database consists of >12 000 patients with a large spectrum of cardiovascular clinical phenotypes. It integrates community-based population cohorts, cardiovascular risk cohorts, and heart failure cohorts. CONCLUSIONS:The FIBROTARGETS biomarker programme is aimed at exploring fibrotic pathways allowing the bioprofiling of patients into specific 'fibrotic' phenotypes and identifying new therapeutic targets that will potentially enable the development of novel and tailored anti-fibrotic therapies for heart failure.

SUBMITTER: Ferreira JP

PROVIDER: S-EPMC5793978 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Rationale of the FIBROTARGETS study designed to identify novel biomarkers of myocardial fibrosis.

Ferreira João Pedro JP Machu Jean-Loup JL Girerd Nicolas N Jaisser Frederic F Thum Thomas T Butler Javed J González Arantxa A Diez Javier J Heymans Stephane S McDonald Kenneth K Gyöngyösi Mariann M Firat Hueseyin H Rossignol Patrick P Pizard Anne A Zannad Faiez F

ESC heart failure 20171007 1

<h4>Aims</h4>Myocardial fibrosis alters the cardiac architecture favouring the development of cardiac dysfunction, including arrhythmias and heart failure. Reducing myocardial fibrosis may improve outcomes through the targeted diagnosis and treatment of emerging fibrotic pathways. The European-Commission-funded 'FIBROTARGETS' is a multinational academic and industrial consortium with the main aims of (i) characterizing novel key mechanistic pathways involved in the metabolism of fibrillary colla ...[more]

PMID: 28988439

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Rationale of the FIBROTARGETS study designed to identify novel biomarkers of myocardial fibrosis.

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Rationale of the FIBROTARGETS study designed to identify novel biomarkers of myocardial fibrosis.

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