Ontology highlight
ABSTRACT:
SUBMITTER: Ather JL
PROVIDER: S-EPMC5794179 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Ather Jennifer L JL Poynter Matthew E ME
PloS one 20180201 2
Serum amyloid A (SAA) is an apolipoprotein that is robustly upregulated in numerous inflammatory diseases and has been implicated as a candidate pro-inflammatory mediator. However, studies comparing endogenous SAAs and recombinant forms of the acute phase protein have generated conflicting data on the function of SAA in immunity. We generated SAA3 knockout mice to evaluate the contribution of SAA3 to immune-mediated disease, and found that mice lacking SAA3 develop adult-onset obesity and metabo ...[more]