The association of single nucleotide polymorphism rs189037C>T in ATM gene with coronary artery disease in Chinese Han populations: A case control study.

ABSTRACT: Accumulated evidence has indicated that ataxia telangiectasia mutated (ATM) is closely related to atherosclerosis and cardiovascular diseases. So we aimed to examine potential association between a gene variant [single nucleotide polymorphisms (SNPs), i.e., rs189037C>T] in the promoter of ATM gene and coronary artery disease (CAD) in Chinese Han populations.In this hospital-based case-control study, a total of 1308 participants were divided into CAD group (652 patients) and control group (656 subjects) after performing coronary angiography. The SNP rs189037 was genotyped by using polymerase chain reaction-restriction fragment length polymorphism.The distribution of rs189037 genotypes and alleles showed a significant difference between CAD and control subjects (genotypes: P?=?.032; alleles: P?=?.028). The percentage of the TT genotype is much higher in control group than that in CAD group (22.0% vs 16.3%, P?=?.009). After adjustment of the major confounding factors, such difference remained significant (OR?=?0.62, 95% CI?=?0.43-0.89, P?=?.010). After analyzing data from different groups divided by genders and smoking status respectively, we found that the protective effect of TT genotype on CAD was significant in males (P?=?.007) and smokers (P?=?.031). The difference remained statistically significant after multivariate adjustment (adjusted in males: OR?=?0.60, 95% CI?=?0.38-0.93, P?=?.022; adjusted in smokers: OR?=?0.47, 95% CI?=?0.27-0.81, P?=?.006).Our study suggests that ATM rs189037 polymorphism is associated with CAD in Chinese Han populations. The TT genotype of rs189037 seems to be associated with a lower risk of CAD and a protective genetic marker of CAD, especially in males and smokers.

SUBMITTER: Ding X 

PROVIDER: S-EPMC5794405 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature