Can the Sum of Adenoma Diameters (Adenoma Bulk) on Index Examination Predict Risk of Metachronous Advanced Neoplasia?

ABSTRACT:

Background

Recent data suggest that adenoma size and number are more important predictors of metachronous colorectal neoplasia than advanced histology. Furthermore, there is poor reproducibility in diagnosing advanced histology; high-grade dysplasia and villous histology. Therefore we developed a new metric, adenoma bulk, the sum of diameters of all baseline adenomas, regardless of advanced features.

Goal

Compare the predictive value for metachronous advanced neoplasia of adenoma bulk to conventional paradigm.

Study

Data were collected prospectively in a multicenter adenoma-chemoprevention trial (2004 to 2013). For the conventional paradigm, high-risk baseline findings were defined as ≥3 adenomas, large adenomas (≥1 cm) or adenomas with villous components or high-grad

SUBMITTER: Anderson JC 

PROVIDER: S-EPMC5794639 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature