Ontology highlight
ABSTRACT:
SUBMITTER: Kim CG
PROVIDER: S-EPMC5794649 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Kim Chang Geun CG Lee Hyemin H Gupta Nehal N Ramachandran Sharavan S Kaushik Itishree I Srivastava Sangeeta S Kim Sung-Hoon SH Srivastava Sanjay K SK
Seminars in cancer biology 20170801
It is now widely accepted that several gene alterations including transcription factors are critically involved in cancer progression and metastasis. Forkhead Box Class O proteins (FoxOs) including FoxO1/FKHR, FoxO3/FKHRL1, FoxO4/AFX and FoxO6 transcription factors are known to play key roles in proliferation, apoptosis, metastasis, cell metabolism, aging and cancer biology through their phosphorylation, ubiquitination, acetylation and methylation. Though FoxOs are proved to be mainly regulated ...[more]