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Prevalence and Risk Factors of self-reported dry eye in Brazil using a short symptom questionnaire.

ABSTRACT: To evaluate dry eye prevalence and investigate associated risk factors in Brazil by applying a short questionnaire of symptoms and risk factors. A cross-sectional study of 3,107 participants from all the five different geopolitical regions of Brazil. Overall prevalence of dry eye in this study population was 12.8%. Dry eye previous diagnosis was reported by 10.2% and presence of severe symptoms in 4.9%. Logistic regression analysis confirmed some significantly risk factors, such as female sex (Odds Ratio (OR) 1.74; 95% Confidence Interval (CI): 1.12-1.93), age ?60 year-old (OR 2.00; 95%CI: 1.44-2.77), history of ocular surgery (OR 1.84; 95%CI: 1.30-2.60), contact lens wear (OR 1.93; 95%CI: 1.36-2.73), cancer treatment (OR 3.03; 95%CI: 1.36-6.59), computer use >6?hours per day (OR 1.77; 95%CI: 1.36-2.31), antidepressants (OR 1.61; 95%CI: 1.12-2.31) and anti-allergy (OR 2.11; 95%CI: 1.54-2.89) medications. Nevertheless, when stratified by regions, each one had its own significant factors and inherent characteristics. This is the first study about prevalence and risk factors of dry eye in a large population sample from all regions of Brazil. Dry eye is a common condition in the Brazilian population and prevalence rates varies substantially in the different geographic regions of the country, possibly reflecting climate and socioeconomic discrepancies.

SUBMITTER: Castro JS

PROVIDER: S-EPMC5794758 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Prevalence and Risk Factors of self-reported dry eye in Brazil using a short symptom questionnaire.

Castro Julia Silvestre de JS Selegatto Iara Borin IB Castro Rosane Silvestre de RS Miranda Eliana C M ECM de Vasconcelos José Paulo Cabral JPC de Carvalho Keila Monteiro KM Arieta Carlos Eduardo Leite CEL Alves Monica M

Scientific reports 20180201 1

To evaluate dry eye prevalence and investigate associated risk factors in Brazil by applying a short questionnaire of symptoms and risk factors. A cross-sectional study of 3,107 participants from all the five different geopolitical regions of Brazil. Overall prevalence of dry eye in this study population was 12.8%. Dry eye previous diagnosis was reported by 10.2% and presence of severe symptoms in 4.9%. Logistic regression analysis confirmed some significantly risk factors, such as female sex (O ...[more]

PMID: 29391426

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Project description:BackgroundDry eye disease (DED), Meibomian gland dysfunction (MGD), and Sjögren's syndrome dry eye disease (SS-DED) are eye dryness conditions that show significant overlap in various symptoms of ocular discomfort. The aim of this study was to qualitatively explore the patient experience and evaluate content validity of the newly developed Dry Eye Disease Questionnaire (DED-Q).MethodsSemi-structured interviews were conducted with 61 US adults who reported experiencing ocular symptoms due to their physician-confirmed primary diagnosis of DED (n = 21), MGD (n = 20), or SS-DED (n = 20). The open-ended concept-elicitation phase was followed by cognitive debriefing (CD) of the DED-Q to evaluate participants' understanding and relevance of the instructions, items, response options, and recall periods. Interviews were also conducted with eight specialist healthcare professionals to assess clinical relevance of the concepts included. Verbatim interview transcripts were analyzed using thematic analysis in ATLAS.ti v8 software.ResultsA total of 29 symptoms and 14 impacts on quality of life were reported across participant interviews. Primary ocular symptoms reported included eye dryness (n = 61/61; 100%), eye irritation (n = 55/61; 90%), eye itch (n = 54/61; 89%), burning sensation (n = 52/61; 85%), and foreign body sensation (n = 51/61; 84%). The most impacted aspects of daily life were using digital screens (n = 46/61; 75%), driving (n = 45/61; 74%), working (n = 39/61; 64%), and reading (n = 37/61; 61%). CD findings showed most participants had good understanding of DED-Q items and confirmed most concepts were relevant to the lived experience of their condition. Aside from few minor changes to the items and examples to facilitate more accurate interpretation, the proposed instruction wording was modified for various symptom and impact modules to encourage participants to focus only on dry eye vision problems.ConclusionsThis research identified multiple prevalent symptoms and impacts of DED, MGD, and SS-DED, most of which were similar across the conditions. The DED-Q was confirmed to be a content-valid PRO measure suitable for use in clinical studies to assess the patient experience of DED, MGD, and SS-DED. Future work will focus on evaluating the psychometric properties of the DED-Q for use as an efficacy endpoint in clinical trials.

Dataset Information

Prevalence and Risk Factors of self-reported dry eye in Brazil using a short symptom questionnaire.

Publications

Prevalence and Risk Factors of self-reported dry eye in Brazil using a short symptom questionnaire.

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