Ontology highlight
ABSTRACT:
SUBMITTER: Armstrong HK
PROVIDER: S-EPMC5794796 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Armstrong Heather K HK Gillis Joanna L JL Johnson Ian R D IRD Nassar Zeyad D ZD Moldovan Max M Levrier Claire C Sadowski Martin C MC Chin Mei Yieng MY Tomlinson Guns Emma S ES Tarulli Gerard G Lynn David J DJ Brooks Douglas A DA Selth Luke A LA Centenera Margaret M MM Butler Lisa M LM
Scientific reports 20180201 1
The molecular chaperone Hsp90 is overexpressed in prostate cancer (PCa) and is responsible for the folding, stabilization and maturation of multiple oncoproteins, which are implicated in PCa progression. Compared to first-in-class Hsp90 inhibitors such as 17-allylamino-demethoxygeldanamycin (17-AAG) that were clinically ineffective, second generation inhibitor AUY922 has greater solubility and efficacy. Here, transcriptomic and proteomic analyses of patient-derived PCa explants identified cytosk ...[more]