Ontology highlight
ABSTRACT:
SUBMITTER: Chang H
PROVIDER: S-EPMC5794872 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Chang H H Hoshina N N Zhang C C Ma Y Y Cao H H Wang Y Y Wu D-D DD Bergen S E SE Landén M M Hultman C M CM Preisig M M Kutalik Z Z Castelao E E Grigoroiu-Serbanescu M M Forstner A J AJ Strohmaier J J Hecker J J Schulze T G TG Müller-Myhsok B B Reif A A Mitchell P B PB Martin N G NG Schofield P R PR Cichon S S Nöthen M M MM Walter H H Erk S S Heinz A A Amin N N van Duijn C M CM Meyer-Lindenberg A A Tost H H Xiao X X Yamamoto T T Rietschel M M Li M M
Molecular psychiatry 20170110 2
Major mood disorders, which primarily include bipolar disorder and major depressive disorder, are the leading cause of disability worldwide and pose a major challenge in identifying robust risk genes. Here, we present data from independent large-scale clinical data sets (including 29 557 cases and 32 056 controls) revealing brain expressed protocadherin 17 (PCDH17) as a susceptibility gene for major mood disorders. Single-nucleotide polymorphisms (SNPs) spanning the PCDH17 region are significant ...[more]