Ontology highlight
ABSTRACT:
SUBMITTER: Lennox AT
PROVIDER: S-EPMC5794982 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Lennox Alison T AT Coburn Stefanie L SL Leech John A JA Heidrich Elisa M EM Kleyman Thomas R TR Wenzel Sally E SE Pilewski Joseph M JM Corcoran Timothy E TE Myerburg Mike M MM
Scientific reports 20180201 1
Allergic airway disease is known to cause significant morbidity due to impaired mucociliary clearance, however the mechanism that leads to the mucus dysfunction is not entirely understood. Interleukin 13 (IL-13), a key mediator of Type 2 (T2) inflammation, profoundly alters the ion transport properties of airway epithelium. However, these electrophysiological changes cannot explain the thick, tenacious airway mucus that characterizes the clinical phenotype. Here we report that IL-13 dramatically ...[more]