Opposing roles of TGF? and BMP signaling in prostate cancer development.
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ABSTRACT:
SUBMITTER: Lu X
PROVIDER: S-EPMC5795781 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
Opposing roles of TGFβ and BMP signaling in prostate cancer development.
Lu Xin X Jin Eun-Jung EJ Cheng Xi X Feng Shan S Shang Xiaoying X Deng Pingna P Jiang Shan S Chang Qing Q Rahmy Sharif S Chaudhary Seema S Lu Xuemin X Zhao Ren R Wang Y Alan YA DePinho Ronald A RA
Genes & development 20171201 23-24
SMAD4 constrains progression of <i>Pten</i>-null prostate cancer and serves as a common downstream node of transforming growth factor β (TGFβ) and bone morphogenetic protein (BMP) pathways. Here, we dissected the roles of TGFβ receptor II (TGFBR2) and BMP receptor II (BMPR2) using a <i>Pten</i>-null prostate cancer model. These studies demonstrated that the molecular actions of TGFBR2 result in both SMAD4-dependent constraint of proliferation and SMAD4-independent activation of apoptosis. In con ...[more]
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