Ontology highlight
ABSTRACT:
SUBMITTER: Tsukiyama-Kohara K
PROVIDER: S-EPMC5795974 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Tsukiyama-Kohara Kyoko K Kohara Michinori M
International journal of molecular sciences 20171222 1
Hepatitis C virus (HCV) mainly replicates in the cytoplasm, where it easily establishes persistent infection, resulting in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Due to its high rate of mutation, HCV forms viral quasispecies, categorized based on the highly variable regions in the envelope protein and nonstructural 5A protein. HCV possesses seven major genotypes, among which genotype 1 is the most prevalent globally. The distribution of HCV genotypes varies based on ge ...[more]