The Dark Side of IFN-?: Its Role in Promoting Cancer Immunoevasion.
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ABSTRACT:
SUBMITTER: Mojic M
PROVIDER: S-EPMC5796039 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Publications
The Dark Side of IFN-γ: Its Role in Promoting Cancer Immunoevasion.
Mojic Marija M Takeda Kazuyoshi K Hayakawa Yoshihiro Y
International journal of molecular sciences 20171228 1
Interferon-γ (IFN-γ) is a pleiotropic cytokine that has long been praised as an important effector molecule of anti-tumor immunity, capable of suppressing tumor growth through various mechanisms. On the contrary to such a bright side of IFN-γ, it has also been involved in promoting an outgrowth of tumor cells with immunoevasive phenotype suggesting an existence of a dark "tumor-promoting" side effect of IFN-γ. In this review, we will summarize this multi-functional role of IFN-γ in tumor context ...[more]
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