Deregulation of Frizzled Receptors in Hepatocellular Carcinoma.
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ABSTRACT:
SUBMITTER: Chan KK
PROVIDER: S-EPMC5796257 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Publications
Deregulation of Frizzled Receptors in Hepatocellular Carcinoma.
Chan Kristy Kwan-Shuen KK Lo Regina Cheuk-Lam RC
International journal of molecular sciences 20180121 1
G protein-coupled receptors (GPCRs) have a substantial role in tumorigenesis and are described as a "cancer driver". Aberrant expression or activation of GPCRs leads to the deregulation of downstream signaling pathways, thereby promoting cancer progression. In hepatocellular carcinoma (HCC), the Wnt signaling pathway is frequently activated and it is associated with an aggressive HCC phenotype. Frizzled (FZD) receptors, a family member of GPCRs, are known to mediate Wnt signaling. Accumulating f ...[more]
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