Ontology highlight
ABSTRACT:
SUBMITTER: Song SE
PROVIDER: S-EPMC5796633 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Song Seung-Eun SE Shin Su-Kyung SK Park So-Young SY Hwang Il-Seon IS Im Seung-Soon SS Bae Jae-Hoon JH Choi Myung-Sook MS Song Dae-Kyu DK
BMB reports 20180101 1
Exchange protein directly activated by cAMP (Epac) 2a-knockout (KO) mice exhibit accelerated diet-induced obesity and are resistant to leptin-mediated adipostatic signaling from the hypothalamus to adipose tissue, with sustained food intake. However, the impact of Epac2a deficiency on hypothalamic regulation of sympathetic nervous activity (SNA) has not been elucidated. This study was performed to elucidate the response of Epac2a-KO mice to dexamethasone-induced muscle atrophy and acute cold str ...[more]