Ontology highlight
ABSTRACT:
SUBMITTER: Krarup AR
PROVIDER: S-EPMC5796873 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Krarup A R AR Abdel-Mohsen M M Schleimann M H MH Vibholm L L Engen P A PA Dige A A Wittig B B Schmidt M M Green S J SJ Naqib A A Keshavarzian A A Deng X X Olesen R R Petersen A M AM Benfield T T Østergaard L L Rasmussen T A TA Agnholt J J Nyengaard J R JR Landay A A Søgaard O S OS Pillai S K SK Tolstrup M M Denton P W PW
Mucosal immunology 20170802 2
Toll-like receptor 9 (TLR9) agonists are being developed for treatment of colorectal and other cancers, yet the impact of these drugs on human intestines remains unknown. This, together with the fact that there are additional potential indications for TLR9 agonist therapy (e.g., autoimmune and infectious diseases), led us to investigate the impact of MGN1703 (Lefitolimod) on intestinal homeostasis and viral persistence in HIV-positive individuals. Colonic sigmoid biopsies were collected (baselin ...[more]