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Diagnostic value of WIF1 methylation for colorectal cancer: a meta-analysis.


ABSTRACT: As a common antagonist of Wnt/?-catenin signaling, Wnt inhibitory factor 1 (WIF1) plays an important role in the tumor progression. The aim of our meta-analysis was to summarize the diagnostic value of WIF1 methylation in colorectal cancer (CRC). Eligible studies were retrieved by a systemic search among PubMed, Embase, CNKI, and Wanfang literature databases. The diagnostic value of WIF1 methylation for CRC was assessed by the summary receiver operating characteristics (SROC) test. Our meta-analysis of 12 studies between 1420 CRC samples and 946 control samples showed that WIF1 hypermethylation was significantly associated with CRC (P < 0.001, OR = 30.10, 95% CI = 19.48-46.50). WIF1 hypermethylation, as a diagnostic biomarker for CRC, has a pooled sensitivity of 0.40 (95% CI: 0.37-0.42), a pooled specificity of 0.95 (95% CI: 0.93-0.96), a pooled positive-likelihood ratio (PLR) of 8.65 (95% CI, 4.47-16.73), and a pooled negative-likelihood ratio (NLR) of 0.41 (95% CI, 0.30-0.55), a diagnostic odds ratio (DOR) of 26.86 (95% CI: 15.73-45.89), and an area under the curve (AUC) of 0.9115. In conclusion, our study established that WIF1 hypermethylation might be a promising diagnostic biomarker for CRC.

SUBMITTER: Hu H 

PROVIDER: S-EPMC5797056 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Diagnostic value of <i>WIF1</i> methylation for colorectal cancer: a meta-analysis.

Hu Haochang H   Li Bin B   Zhou Cong C   Ying Xiuru X   Chen Min M   Huang Tianyi T   Chen Yuehong Y   Ji Huihui H   Pan Ranran R   Wang Tiangong T   Jiang Danjie D   Chen Yanfei Y   Yang Yong Y   Duan Shiwei S  

Oncotarget 20180103 4


As a common antagonist of Wnt/β-catenin signaling, Wnt inhibitory factor 1 (<i>WIF1</i>) plays an important role in the tumor progression. The aim of our meta-analysis was to summarize the diagnostic value of <i>WIF1</i> methylation in colorectal cancer (CRC). Eligible studies were retrieved by a systemic search among PubMed, Embase, CNKI, and Wanfang literature databases. The diagnostic value of <i>WIF1</i> methylation for CRC was assessed by the summary receiver operating characteristics (SROC  ...[more]

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