Ontology highlight
ABSTRACT:
SUBMITTER: Yamamoto Y
PROVIDER: S-EPMC5797116 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Yamamoto Yasunori Y Sakisaka Toshiaki T
Scientific reports 20180202 1
The endoplasmic reticulum (ER) is shaped by a class of membrane proteins containing reticulon homology domain (RHD), the conserved hydrophobic domain encompassing two short hairpin transmembrane domains. RHD resides in the outer leaflet of the ER membrane, generating high-curvature ER membrane. While most of the membrane proteins destined to enter the secretory pathway are cotranslationally targeted and inserted into ER membrane, the molecular mechanism how the RHD-containing proteins are target ...[more]