Ontology highlight
ABSTRACT:
SUBMITTER: Lo CY
PROVIDER: S-EPMC5797126 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Lo Chun-Yeung CY Li Olive Tin-Wai OT Tang Wen-Ping WP Hu Chun C Wang Guo Xin GX Ngo Jacky Chi-Ki JC Wan David Chi-Cheong DC Poon Leo Lit-Man LL Shaw Pang-Chui PC
Scientific reports 20180202 1
Currently, many strains of influenza A virus have developed resistance against anti-influenza drugs, and it is essential to find new chemicals to combat this virus. The influenza polymerase with three proteins, PA, PB1 and PB2, is a crucial component of the viral ribonucleoprotein (RNP) complex. Here, we report the identification of a hit compound 221 by surface plasmon resonance (SPR) direct binding screening on the C-terminal of PA (PAC). Compound 221 can subdue influenza RNP activities and at ...[more]