Ouabagenin is a naturally occurring LXR ligand without causing hepatic steatosis as a side effect.
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ABSTRACT:
SUBMITTER: Tamura S
PROVIDER: S-EPMC5797171 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
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Ouabagenin is a naturally occurring LXR ligand without causing hepatic steatosis as a side effect.
Tamura Satoru S Okada Maiko M Kato Shigeaki S Shinoda Yasuharu Y Shioda Norifumi N Fukunaga Kohji K Ui-Tei Kumiko K Ueda Minoru M
Scientific reports 20180202 1
Ouabagenin (OBG) is an aglycone of the cardiotonic steroid ouabain and until now was considered a biologically inactive biosynthetic precursor. Herein, we revealed that OBG functions as a novel class of ligand for the liver X receptor (LXR). Luciferase reporter assays and in silico docking studies suggested that OBG has LXR-selective agonistic activity. In addition, OBG repressed the expression of epithelial sodium channel (ENaC), a LXR target gene, without causing hepatic steatosis, a typical s ...[more]
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